Reversal of streptokinase induced bleeding with aprotinin for emergency cardiac surgery
نویسندگان
چکیده
منابع مشابه
Prevalence and Causes of Mediastinal Reexploration for Excessive Bleeding after Cardiac Surgery Procedures
Introduction: Postoperative bleeding in cardiac surgery is not an uncommon complication and can be evaluated with surgical and nonsurgical causes. Although any type of coagulopathy should be treated before, during, and after the surgical procedure, cardiac surgeons should have perfect surgical techniques for step by step hemostasis to minimize blood loss. Material...
متن کاملA disheartening story: Aprotinin in cardiac surgery
Results: In propensity-adjusted, multivariable logistic regression (C-index, 0.72), use of aprotinin was associated with a doubling in the risk of renal failure requiring dialysis among patients undergoing complex coronary-artery surgery (odds ratio, 2.59; 95 percent confidence interval, 1.36 to 4.95) or primary surgery (odds ratio, 2.34; 95 percent confidence interval, 1.27 to 4.31). Similarly...
متن کاملCon: Aprotinin has a good efficacy and safety profile relative to other alternatives for prevention of bleeding in cardiac surgery.
W. Scott Beattie, MD, PhD, FRCPC* Keyvan Karkouti, MD, MSc, FRCPC*† It is our position that, to reduce perioperative blood loss in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB), all patients should receive a drug with antifibrinolytic properties (heretofore referred to as “antifibrinolytic drugs”), and that the drug of choice for this indication in most (if not all) pati...
متن کاملPro: Aprotinin has a good efficacy and safety profile relative to other alternatives for prevention of bleeding in cardiac surgery.
Simon C. Body, MBChB, MPH* C. David Mazer, MD, FRCPC† Two recently published reports have evoked partisan debate and regulatory review on the safety of the widely used protease inhibitor, aprotinin (Bayer Pharma, West Haven, CT) (1,2). These retrospective observational studies claimed significant increases in several adverse postoperative events after cardiac surgery, without important reductio...
متن کاملIs epsilon-aminocaproic acid as effective as aprotinin in reducing bleeding with cardiac surgery?: a meta-analysis.
BACKGROUND Although aprotinin is known to be effective in reducing postoperative hemorrhage after cardiac surgery, epsilon-aminocaproic acid, an alternative antifibrinolytic, is considerably less expensive. Because the results of 3 small randomized clinical trials comparing these 2 agents directly were inconclusive, we performed a meta-analysis to compare the relative effectiveness and adverse-...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 1992
ISSN: 0003-2409,1365-2044
DOI: 10.1111/j.1365-2044.1992.tb02125.x